Led by Dr. Emmanuel "Chip" Walter, Professor of Pediatrics, the DVTU has conducted numerous studies in our infant and adolescent population. Dr. Walter is the principal investigator for the Clinical Immunization Safety Assessment (CISA) Project at Duke and the co-principal investigator for the NIAID-sponsored Vaccine and Treatment Evaluation Unit (VTEU) at Duke. Although much of Dr. Walter’s early research career was focused on pediatric HIV infection, Dr. Walter has a long standing clinical and research interest in immunization issues. Either as a principal investigator or co-investigator he has been conducting clinical vaccine studies including Phase I, II, III and IV vaccine evaluations for over 20 years. He directs the Duke Vaccine and Trials Unit (DVTU), is a member of the Duke Human Vaccine Institute, and co-directs the Duke Primary Care Research Consortium at the Duke Clinical Research Institute. Most recently he has published primarily in the field of vaccines with a particular emphasis on early childhood influenza immunization. Dr. Walter currently serves as a member for the CDC Advisory Committee on Immunization Practices. The current studies Dr. Walter leads are below:
- Dr. Greenberg and Dr. Walter are leading a multicenter study to assess apnea following vaccination in premature infants receiving their standard of care two-month vaccinations. Furhtur informatiom about this study can be found at clinicaltrials.gov.
- Dr. Walter and Dr. Greenberg are conducting a study to assess the population pharmacokinetics of moxifloxacin administered to children per clinical care.
- Dr. Walter is leading the Duke site in a study to evaluate the safety of Quadrivalent Live Attenuated Influenza Vaccine (LAIV4) in children with asthma of varying levels of severity. The study is multicenter and will be enrolling 300 children. Subjects will be randomized to receive either LAIV4 or IIV4.
- Dr. Walter is leading a study to assess the feasibility of using clinic-based interventions (Buzzy alone, music alone, or Buzzy and music together) to prevent post-vaccination presyncope in adolescents.The study is single site and enrolling 30 adolescents, 10-17 years of age. More information about the trial can be found at clinicaltrials.gov.