About Us

The Duke Vaccine and Trials Unit (DVTU), as part of the Human Vaccine Institute, is a consortium of investigators committed to conducting clinical investigations related to the control and prevention of infectious disease.  We have overarching goals of furthering our understanding of vaccine immune responses, correlates of protection from infection and enhancing vaccine safety.

The DVTU was initially founded in the 1980s and early work helped assist with the licensure of a Haemophilus influenzae type B vaccine to prevent childhood meningitis and the chicken pox vaccine. Since that time, the DVTU has conducted evaluations of numerous vaccines and treatments against an array of infectious agents including:

  • Hepatitis A
  • Smallpox
  • Seasonal and pandemic influenza
  • Pertussis
  • Rotavirus
  • Pneumococcus
  • Human papilloma virus
  • Meningococcus
  • West Nile Virus
  • Botulism Toxin
  • Clostridium difficile

In addition to vaccine and treatment evaluations, the unit also conducts antimicrobial pharmacokinetic trials, population pharmacokinetics, and epidemiologic investigations. Unit studies range from Phase 1 to Phase 4 and include infants, children, adolescents, adults, pregnant women, and older adults. Studies are supported by the NIH DMID, the CDC and various industry sponsors.