Duke University is a member of the Centers for Disease Control and Prevention (CDC) sponsored Clinical Immunization Safety Assessment (CISA) Project. As part of the national network, Duke assists safety experts from the CDC’s Immunization Safety Office (ISO) in providing a comprehensive vaccine safety public health service to the nation. The mission of the CISA project is to improve understanding of adverse events following immunization (AEFI) at the individual-patient level. Project goals include: 1) serving as a vaccine safety resource for consultation on clinical vaccine safety issues; 2) developing strategies to assess individuals who may be at increased risk for AEFI; 3) conducting studies to identify risk factors and preventive strategies for AEFI, particularly in special populations. More specifically Duke assists with clinical case evaluation for US healthcare providers who have vaccine safety questions about a specific patient residing in the US and provides consultation that enhances understanding of vaccine safety issues and informs clinical and public health practices.
Duke investigators are currently conducting a number of studies to assess vaccine safety in special populations and to evaluate potential strategies to prevent AEFI. The Duke Human Vaccine Institute (DHVI) plays a critical role by providing the necessary infrastructure to conduct laboratory assessments for Duke CISA activities.
- Boston Medical Center, Boston, MA
Principal Investigator: Colin Marchant, MD and Elizabeth Barnett, MD
- Children's Hospital Medical Center, Cincinnati, Ohio
Principal Investigator: Steven Black, MD, Mary Staat, MD, MPH, and Elizabeth Schlaudecker, MD, MPH
- Columbia University, New York, NY
Principal Investigator: Anne Gershon, MD, Philip LaRussa, MD, and Melissa Stockwell, MD, MPH
- Johns Hopkins University, Baltimore, MD
Principal Investigator: Neal Halsey, MD and Kawsar Talaat, MD
- Kaiser Permanente Northern California, CA
Principal Investigator: Nicola Klein, M.D., Ph.D.
- Vanderbilt University, Nashville, Tennessee
Principal Investigator: Kathryn Edwards, MD. and Buddy Creech, MD, MPH